Vanderbilt-Ingram Cancer Center

The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers

Barbara Fingleton, Ph.D.

Assistant Professor

Contact Information:

Vanderbilt-Ingram Cancer Center
734 Preston Building
Nashvill, TN 37232-6840
615-936-5877
Fax: 615-936-2911

Research Specialty:

inflammation and cancer - especially colon cancer

Research Description:

My background is in the area of matrix metalloproteinases (MMPs) and how they contribute to cancer development and progression. I have been especially interested in testing drugs that can inhibit MMPs in cancer models and in understanding why such drugs have not been effective in human cancer patients. Lately, I have focused on some of the roles of specific MMPs in pre-cancerous inflammatory conditions, particularly colitis. Additionally, I work on cytokines and their receptors and how these molecules can influence cancer development and progression on the background of inflammatory bowel disease.

Publications:

• Sinnamon, MJ, Carter, KJ, Sims, LP, Lafleur, B, Fingleton, B, Matrisian, LM A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis, 29(4), 880-6, 2008.
• Martin, MD, Carter, KJ, Jean-Philippe, SR, Chang, M, Mobashery, S, Thiolloy, S, Lynch, CC, Matrisian, LM, Fingleton, B Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res, 68(15), 6251-9, 2008.
• Martin, MD, Fingleton, B, Lynch, CC, Wells, S, McIntyre, JO, Piston, DW, Matrisian, LM Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin Exp Metastasis, 25(8), 877-85, 2008.
• Quarles, CC, Lepage, M, Gorden, DL, Fingleton, B, Yankeelov, TE, Price, RR, Matrisian, LM, Gore, JC, McIntyre, JO Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med, 60(3), 718-26, 2008.
• Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Yull, FE, Blackwell, TS, Fingleton, B Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol Cancer Res, 6(3), 364-71, 2008.
• Sinnamon, MJ, Carter, KJ, Fingleton, B, Matrisian, LM Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse. Int J Exp Pathol, 89(6), 466-75, 2008.
• Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Polosukhin, VV, Fingleton, B, Yull, FE, Blackwell, TS Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin Exp Metastasis, 25(1), 43-51, 2008.
• Ogden, SR, Wroblewski, LE, Weydig, C, Romero-Gallo, J, O''Brien, DP, Israel, DA, Krishna, US, Fingleton, B, Reynolds, AB, Wessler, S, Peek, RM p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell, 19(10), 4110-21, 2008.
• Fingleton, B, Powell, WC, Crawford, HC, Couchman, JR, Matrisian, LM A Rat Monoclonal Antibody That Recognizes Pro- And Active MMP-7 Indicates Polarized Expression In Vivo. Hybridoma (Larchmt), 26(1), 22-7, 2007.
• Stathopoulos, GT, Sherrill, TP, Cheng, DS, Scoggins, RM, Han, W, Polosukhin, VV, Connelly, L, Yull, FE, Fingleton, B, Blackwell, TS Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A, 104(47), 18514-9, 2007.
• Schwartz, DR, Moin, K, Yao, B, Matrisian, LM, Coussens, LM, Bugge, TH, Fingleton, B, Acuff, HB, Sinnamon, M, Nassar, H, Platts, AE, Krawetz, SA, Linebaugh, BE, Sloane, BF Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res, 5(5), 443-54, 2007.
• Fingleton, B, Carter, KJ, Matrisian, LM Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res, 67(10), 4800-6, 2007.
• Fingleton, B MMPs as therapeutic targets-Still a viable option. Semin Cell Dev Biol, 2007.
• Lynch, CC, Vargo-Gogola, T, Martin, MD, Fingleton, B, Crawford, HC, Matrisian, LM Matrix Metalloproteinase 7 Mediates Mammary Epithelial Cell Tumorigenesis through the ErbB4 Receptor. Cancer Res, 67(14), 6760-7, 2007.
• Fingleton, B Matrix metalloproteinases as valid clinical targets. Curr Pharm Des, 13(3), 333-46, 2007.
• Fingleton, B Molecular targets in metastasis: lessons from genomic approaches. Cancer Genomics Proteomics, 4(3), 211-21, 2007.
• Lepage, M, Dow, WC, Melchior, M, You, Y, Fingleton, B, Quarles, CC, P??pin, C, Gore, JC, Matrisian, LM, McIntyre, JO Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging, 6(6), 393-403, 2007.
• Gorden, DL, Fingleton, B, Crawford, HC, Jansen, DE, Lepage, M, Matrisian, LM Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int J Cancer, 2007.
• Acuff, HB, Sinnamon, M, Fingleton, B, Boone, B, Levy, SE, Chen, X, Pozzi, A, Carbone, DP, Schwartz, DR, Moin, K, Sloane, BF, Matrisian, LM Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res, 66(16), 7968-75, 2006.
• Acuff, HB, Carter, KJ, Fingleton, B, Gorden, DL, Matrisian, LM Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res, 66(1), 259-66, 2006.
• Fingleton, B Matrix metalloproteinases: roles in cancer and metastasis. Front Biosci, 11479-91, 2006.
• Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis, 22(2), 185-93, 2005.
• Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer, 116(1), 52-61, 2005.
• Lynch, CC, Hikosaka, A, Acuff, HB, Martin, MD, Kawai, N, Singh, RK, Vargo-Gogola, TC, Begtrup, JL, Peterson, TE, Fingleton, B, Shirai, T, Matrisian, LM, Futakuchi, M MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell, 7(5), 485-96, 2005.
• Harrell, PC, McCawley, LJ, Fingleton, B, McIntyre, JO, Matrisian, LM Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp Cell Res, 303(2), 308-20, 2005.
• Mohammed, FF, Smookler, DS, Taylor, SE, Fingleton, B, Kassiri, Z, Sanchez, OH, English, JL, Matrisian, LM, Au, B, Yeh, WC, Khokha, R Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet, 36(9), 969-77, 2004.
• McIntyre, JO, Fingleton, B, Wells, KS, Piston, DW, Lynch, CC, Gautam, S, Matrisian, LM Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J, 377(Pt 3), 617-28, 2004.
• Yang, L, DeBusk, LM, Fukuda, K, Fingleton, B, Green-Jarvis, B, Shyr, Y, Matrisian, LM, Carbone, DP, Lin, PC Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell, 6(4), 409-21, 2004.
• Fingleton, B, Menon, R, Carter, KJ, Overstreet, PD, Hachey, DL, Matrisian, LM, McIntyre, JO Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin Cancer Res, 10(23), 7865-74, 2004.
• Gustavson, MD, Crawford, HC, Fingleton, B, Matrisian, LM Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol Carcinog, 41(3), 125-39, 2004.
• Hulboy, DL, Gautam, S, Fingleton, B, Matrisian, LM The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep, 12(1), 13-7, 2004.
• Fingleton, B CMT-3. CollaGenex. Curr Opin Investig Drugs, 4(12), 1460-7, 2003.
• Fingleton, B Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects. Expert Opin Ther Targets, 7(3), 385-97, 2003.
• Vargo-Gogola, T, Crawford, HC, Fingleton, B, Matrisian, LM Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch Biochem Biophys, 408(2), 155-61, 2002.
• Vargo-Gogola, T, Fingleton, B, Crawford, HC, Matrisian, LM Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer Res, 62(19), 5559-63, 2002.
• Fingleton, B, Vargo-Gogola, T, Crawford, HC, Matrisian, LM Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis. Neoplasia, 3(6), 459-68, 2002.
• Coussens, LM, Fingleton, B, Matrisian, LM Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science, 295(5564), 2387-92, 2002.
• Fingleton, B, Matrisian, LM Matrix metalloproteinases as targets for therapy in Kaposi sarcoma. Curr Opin Oncol, 13(5), 368-73, 2001.
• No? Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci, 114(Pt 1), 111-118, 2001.
• Crawford, HC, Fingleton, B, Gustavson, MD, Kurpios, N, Wagenaar, RA, Hassell, JA, Matrisian, LM The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol, 21(4), 1370-83, 2001.
• Haro, H, Crawford, HC, Fingleton, B, MacDougall, JR, Shinomiya, K, Spengler, DM, Matrisian, LM Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J Clin Invest, 105(2), 133-41, 2000.
• Haro, H, Crawford, HC, Fingleton, B, Shinomiya, K, Spengler, DM, Matrisian, LM Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J Clin Invest, 105(2), 143-50, 2000.
• Nelson, AR, Fingleton, B, Rothenberg, ML, Matrisian, LM Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol, 18(5), 1135-49, 2000.
• Fingleton, BM, Heppner Goss, KJ, Crawford, HC, Matrisian, LM Matrilysin in early stage intestinal tumorigenesis. APMIS, 107(1), 102-10, 1999.
• Crawford, HC, Fingleton, BM, Rudolph-Owen, LA, Goss, KJ, Rubinfeld, B, Polakis, P, Matrisian, LM The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene, 18(18), 2883-91, 1999.
• Powell, WC, Fingleton, B, Wilson, CL, Boothby, M, Matrisian, LM The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol, 9(24), 1441-7, 1999.
• Fingleton, B, McDonnell, S Cytokine regulation of matrilysin gene expression. Biochem Soc Trans, 25(2), 155S, 1997.
• McDonnell, S, Fingleton, B Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors. Cytotechnology, 12(1-3), 367-84, 1993.